CNQX disodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CNQX disodium 是神经元培养物中的竞争性非 NMDA 受体拮抗剂和竞争性 AMPA/红藻氨酸受体拮抗剂。

CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.The ED50 for ?CNQX was 45.9+/-4.65 microg, respectively.?Intrathecal injection of a combination of CNQX and gabapentin produced a strong synergistic antiallodynic effect in neuropathic rats.

CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices. CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.

CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval. The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg. Animal Model:Male Wistar rats weighing 180-200 g Dosage:0.75, 1.5, and 3 mg/kg Administration:IP; 20 min before testing Result:Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.

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Membrane Transporter/Ion Channel

iGluR

AMPAR

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479347-85-8

276.12

C9H2N4Na2O4?

>98% (HPLC)

In Vitro:?DMSO : 10.53 mg/mL (38.14 mM)

[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years